Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-
like effects in animal studies. This study investigated the effects of the combined
administration of agmatine with either conventional monoaminergic antidepressants or the N-
methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in
mice. The aim was to evaluate the extent of the antidepressant synergism by examining the
ability of a fixed dose of agmatine to shift the antidepressant potency of fluoxetine …