Factors involved in regulating trophoblast fusion: potential role in the development of preeclampsia
M Gauster, G Moser, K Orendi, B Huppertz - Placenta, 2009 - Elsevier
In the human placenta, turnover of villous trophoblast involves proliferation, differentiation
and fusion of mononucleated cytotrophoblasts with the overlying syncytiotrophoblast. In this
way the syncytiotrophoblast is continuously supplied with compounds derived from the
fusing cytotrophoblasts. Acquisition of fresh cellular components is balanced by a
concomitant release of apoptotic material as syncytial knots from the syncytiotrophoblast to
the maternal circulation. In the turnover of villous trophoblast, fusion is an essential step and …
and fusion of mononucleated cytotrophoblasts with the overlying syncytiotrophoblast. In this
way the syncytiotrophoblast is continuously supplied with compounds derived from the
fusing cytotrophoblasts. Acquisition of fresh cellular components is balanced by a
concomitant release of apoptotic material as syncytial knots from the syncytiotrophoblast to
the maternal circulation. In the turnover of villous trophoblast, fusion is an essential step and …