Breaking fat! How mycobacteria and other intracellular pathogens manipulate host lipid droplets

C Barisch, T Soldati - Biochimie, 2017 - Elsevier
Tuberculosis (Tb) is a lung infection caused by Mycobacterium tuberculosis (Mtb). With one
third of the world population latently infected, it represents the most prevalent bacterial
infectious diseases worldwide. Typically, persistence is linked to so-called “dormant” slow-
growing bacteria, which have a low metabolic rate and a reduced response to antibiotic
treatments. However, dormant bacteria regain growth and virulence when the immune
system is weakened, leading again to the active form of the disease. Fatty acids (FAs) …