[HTML][HTML] SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer
T Wilbertz, P Wagner, K Petersen, AC Stiedl… - Modern pathology, 2011 - Elsevier
The transcription factor SOX2 (3q26. 3–q27) is a key regulator of foregut development and
an embryonic stem cell factor cooperating during induction of pluripotency in terminally
differentiated somatic cells. Recently, we found SOX2 to be amplified in a subset of
squamous cell lung and esophageal cancers. The aim of this study was to explore the
prognostic role of SOX2 in a large series of squamous cell carcinomas and
adenocarcinomas of the lung. A total of 891 samples from two independent population …
an embryonic stem cell factor cooperating during induction of pluripotency in terminally
differentiated somatic cells. Recently, we found SOX2 to be amplified in a subset of
squamous cell lung and esophageal cancers. The aim of this study was to explore the
prognostic role of SOX2 in a large series of squamous cell carcinomas and
adenocarcinomas of the lung. A total of 891 samples from two independent population …