[HTML][HTML] ATM phosphorylates histone H2AX in response to DNA double-strand breaks
S Burma, BP Chen, M Murphy, A Kurimasa… - Journal of Biological …, 2001 - ASBMB
A very early step in the response of mammalian cells to DNA double-strand breaks is the
phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the
phosphatidylinositol 3-kinases, DNA-PK (DNA-dependent proteinkinase), ATM (ataxia
telangiectasiamutated), and ATR (ATM andRad3-related), have all been implicated in H2AX
phosphorylation, the specific kinase involved has not yet been identified. To definitively
identify the specific kinase (s) that phosphorylates H2AX in vivo, we have utilized DNA …
phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the
phosphatidylinositol 3-kinases, DNA-PK (DNA-dependent proteinkinase), ATM (ataxia
telangiectasiamutated), and ATR (ATM andRad3-related), have all been implicated in H2AX
phosphorylation, the specific kinase involved has not yet been identified. To definitively
identify the specific kinase (s) that phosphorylates H2AX in vivo, we have utilized DNA …
