[HTML][HTML] Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells
NAD is essential for cellular metabolism and has a key role in various signaling pathways in
human cells. To ensure proper control of vital reactions, NAD must be permanently
resynthesized. Nicotinamide and nicotinic acid as well as nicotinamide riboside (NR) and
nicotinic acid riboside (NAR) are the major precursors for NAD biosynthesis in humans. In
this study, we explored whether the ribosides NR and NAR can be generated in human
cells. We demonstrate that purified, recombinant human cytosolic 5′-nucleotidases (5 …
human cells. To ensure proper control of vital reactions, NAD must be permanently
resynthesized. Nicotinamide and nicotinic acid as well as nicotinamide riboside (NR) and
nicotinic acid riboside (NAR) are the major precursors for NAD biosynthesis in humans. In
this study, we explored whether the ribosides NR and NAR can be generated in human
cells. We demonstrate that purified, recombinant human cytosolic 5′-nucleotidases (5 …