[HTML][HTML] Translational regulation of Hsp90 mRNA: Aug-proximal 5′-untranslated region elements essential for preferential heat shock translation
R Ahmed, RF Duncan - Journal of Biological Chemistry, 2004 - ASBMB
Heat shock in Drosophila results in repression of most normal (non-heat shock) mRNA
translation and the preferential translation of the heat shock mRNAs. The sequence
elements that confer preferential translation have been localized to the 5′-untranslated
region (5′-UTR) for Hsp22 and Hsp70 mRNAs (in Drosophila). Hsp90 mRNA is unique
among the heat shock mRNAs in having extensive secondary structure in its 5′-UTR and
being abundantly represented in the non-heat shocked cell. In this study, we show that …
translation and the preferential translation of the heat shock mRNAs. The sequence
elements that confer preferential translation have been localized to the 5′-untranslated
region (5′-UTR) for Hsp22 and Hsp70 mRNAs (in Drosophila). Hsp90 mRNA is unique
among the heat shock mRNAs in having extensive secondary structure in its 5′-UTR and
being abundantly represented in the non-heat shocked cell. In this study, we show that …