First published March 2, 2015 - More info
Original citation: J Clin Invest. 2014;124(6):2348–2354. doi:10.1172/JCI72273.
Citation for this corrigendum: J Clin Invest. 2015;125(3):1365. doi:10.1172/JCI81182.
In the original article, it was incorrectly stated that “Human CD46 (murine homolog Crry), also known as membrane cofactor protein (MCP), has similar decay-accelerating function, but also exhibits cofactor activity.” Human CD46 has only cofactor activity; it does not have decay-accelerating activity. The corrected sentences appear below.
Human CD46, also known as membrane cofactor protein (MCP), exhibits cofactor activity: in conjunction with soluble factor I, this membrane-bound regulator inactivates C3b to iC3b, thereby preventing reformation of the C3 convertase. The murine homolog of CD46, Crry, has both cofactor activity and decay-accelerating activity.
The authors regret the error.